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KMID : 0882420150880060643
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Korean Journal of Medicine
2015 Volume.88 No. 6 p.643 ~ p.646
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Treatment of Hepatitis C in Special Conditions: Liver Cirrhosis
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Gwak Geum-Youn
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Abstract
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Acquiring a sustained virological response (SVR) in patients with cirrhosis or advanced hepatic fibrosis reduces liver disease-related mortality and the incidence of hepatocellular carcinoma. However, the SVR rate of the current standard of care, which is combination therapy with peg-interferon-alpha and ribavirin, is significantly lower, and treatment-related complications occur more frequently in patients with cirrhosis. Thus, antiviral treatment should be individualized in this population. This review high-lights the issues associated with anti-hepatitis C virus treatment in patients with compensated and decompensated cirrhosis.
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KEYWORD
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Hepatitis C, Cirrhosis, SVR, Antiviral therapy
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